By Enda Brady, Sky News Correspondent
Undergoing hormone replacement therapy (HRT) could increase a woman's risk of getting ovarian cancer by as much as 40%, according to a new study.
The research by Oxford University and published in The Lancet has been welcomed by cancer charities, who are urging more women to study the risks before deciding if they want the treatment.
Around 7,000 women in the UK are diagnosed with ovarian cancer annually and 4,300 women a year die from it - 12 a day.
Liz Aram, from southwest London, underwent HRT for five years and was subsequently diagnosed with ovarian cancer.
She is now in remission, but says if she had read this report at the time she was making her decision on HRT, she would have made a different choice.
"I think if I had known this information back then, I probably would have tried to live longer with the symptoms I was experiencing," she said.
"I would have just worked on and worked through the tiredness I was feeling as a result of going through the menopause, I would have just soldiered on.
"I think knowing that there's a killer disease and the risk could be increased would have put me off it."
Cancer charities are urging women to talk to their GP about the risks involved before making their final decision on whether or not to have HRT.
"Research had already shown an increased risk of ovarian cancer for women using HRT for longer than five years," said Fiona Osgun, from Cancer Research UK.
"But this new, comprehensive analysis shows there's also a risk if you use HRT for less time than that. Once a woman stops taking HRT her risk of ovarian cancer can go back down over time.
"HRT is effective at reducing symptoms of menopause and there are many factors at play in a woman's decision to use it or not. If you are thinking of stopping or starting HRT speak to your GP."
The Medicines and Healthcare Regulatory Agency (MHRA) said it will now evaluate the findings.
"Our advice has always been that the lowest effective dose of HRT should be used for the shortest possible time," said Dr Sarah Branch, deputy director of MHRA's Vigilance and Risk Management of Medicines Division.
"We will evaluate the findings of this study and its implications for shorter term use and update product information as necessary.
"The decision to start, continue or stop HRT should be made jointly by a woman and her doctor, based on the best advice available and her own personal circumstances, including her age, her need for treatment and her medical risk factors."
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